Anti-Hu CD319 Purified
CD319 is a homophilic type I transmembrane protein with two intracellular immunoreceptor tyrosine-based switch motives (ITSMs) . It is expressed by cytotoxic T cells, activated B cells and plasma cells, NK cells, and mature dendritic cells. CD319 triggers NK cell-mediated cytotoxicity. Ligation of CD319 can induce proliferation, cell adhesion, cytokine secretion, and cytotoxicity of T cells and NK cells.
Product Specifications
Certification
RUO
Reactivity
Human
Immunogen
Recombinant extracellular domain of human CD319 (204 aa) fused with Fc part of human IgG1
Target Antigen
CD319
Clone
162
Applications
IHC-P, FC (QC tested), IP
Concentration
1 mg/mL
Format
Purified
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Chan WK, Kang S, Youssef Y, Glankler EN, Barrett ER, Carter AM, Ahmed EH, Prasad A, Chen L, Zhang J, Benson DM Jr, Caligiuri MA, Yu J: A CS1-NKG2D bispecific antibody collectively activates cytolytic immune cells against multiple myeloma. Cancer Immunol Res. 2018 Jul;6 (7) :776-787. , URL: https://pubmed.ncbi.nlm.nih.gov/29769244/
Storage Conditions
Store at 2-8°C. Do not freeze.
Specificity
The mouse monoclonal antibody 162 recognizes an extracellular epitope of human CD319, a transmembrane glycoprotein expressed by cytotoxic T cells, activated B cells, NK cells, and mature dendritic cells.
Applications Notes
Flow cytometry: Recommended dilution: 1-4 μg/ml.
Isotype
Mouse IgG2b
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