CSNK2-IN-2

CSNK2-IN-2 (compound 2) is an orally active CSNK2 inhibitor. CSNK2-IN-2 has an IC50 of 29 μM against CLK11. CSNK2-IN-2 has a half-life of 2.5 h and an AUC of 10,100 h x nM. CSNK2-IN-2 can be used in antiviral studies[1].

Product Specifications

UNSPSC

12352211

Target

Casein Kinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Stem Cell/Wnt

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/csnk2-in-2.html

Smiles

CCC(NC1=CC(NC2=NC3=C(C#N)C=NN3C(NC4CC4)=C2)=C(F)C=C1N5C[C@@H](NC)CCC5)=O

Molecular Formula

C25H30FN9O

Molecular Weight

491.56

References & Citations

[1]Ong HW, et al. Strategic Fluorination to Achieve a Potent, Selective, Metabolically Stable, and Orally Bioavailable Inhibitor of CSNK2. Molecules. 2024 Sep 2;29 (17) :4158.