Ac-YVAD-pNA

Ac-YVAD-pNA is a specific Caspase-1 substrate. Ac-YVAD-pNA can be used to detect Caspase-1 activity. Caspase-1 is a key mediator of inflammatory processes[1][2].

Product Specifications

CAS Number

[149231-66-3]

UNSPSC

12352209

Target

Caspase

Type

Peptides

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ac-yvad-pna.html

Purity

99.93

Solubility

DMSO : ≥ 250 mg/mL

Smiles

O=C(NC1=CC=C([N+]([O-])=O)C=C1)[C@H](CC(O)=O)NC([C@H](C)NC([C@H](C(C)C)NC([C@@H](NC(C)=O)CC2=CC=C(O)C=C2)=O)=O)=O

Molecular Formula

C29H36N6O10

Molecular Weight

628.63

References & Citations

[1]Pereira NA, et al. Some commonly used caspase substrates and inhibitors lack the specificity required to monitor individual caspase activity. Biochem Biophys Res Commun. 2008 Dec 19;377 (3) :873-7. |[2]Xin W, Wang Q, et al. A new mechanism of inhibition of IL-1β secretion by celastrol through the NLRP3 inflammasome pathway. Eur J Pharmacol. 2017 Nov 5;814:240-247.