GS-9851

GS-9851 (PSI-7851) is an HCV nonstructural protein 5B (NS5B) inhibitor with potential activity for the treatment of HCV infection. GS-9851 showed good tolerability in patients with initial HCV genotype 1 infection. GS-9851 is rapidly cleared from the body with a half-life of approximately 1 hour. The maximum concentration of GS-9851 and the increase in the area under the compound concentration-time curve were not dose-proportional, especially at the highest dose[1].

Product Specifications

CAS Number

[1064684-44-1]

Product Name Alternative

PSI-7851

UNSPSC

12352005

Hazard Statement

H315-H317-H319-H335-H360

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/gs-9851.html

Smiles

F[C@]1(C)[C@H](O)[C@@H](COP(N[C@H](C(OC(C)C)=O)C)(OC2=CC=CC=C2)=O)O[C@H]1N3C(NC(C=C3)=O)=O

Molecular Formula

C22H29FN3O9P

Molecular Weight

529.45

Precautions

P261-P264-P271-P272-P280-P302+P352-P304+P340-P362+P364-P405-P501

References & Citations

[1]Discovery of a β-D-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus J. Med. Chem., Article ASAP DOI: 10.1021/jm100863x Publication Date (Web) : September 16, 2010|[2]Pharmacokinetics, pharmacodynamics, and tolerability of GS-9851, a nucleotide analog polymerase inhibitor, following multiple ascending doses in patients with chronic hepatitis C infection