SAHA-BPyne

SAHA-BPyne is an activity-based protein profiling (ABPP) probe for detecting HDAC activity, which covalently labels the proximal proteins through a photoactivation. SAHA-BPyne inhibits HDAC activity in HeLa nuclear lysate with an IC50 of less than 5 μM[1].

Product Specifications

CAS Number

[930772-88-6]

UNSPSC

12352005

Hazard Statement

H225-H301+H311+H331-H370

Target

Fluorescent Dye

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/saha-bpyne.html

Solubility

10 mM in DMSO

Smiles

O=C(NO)CCCCCCC(NC1=CC=C(C(C2=CC=C(NC(CCCC#C)=O)C=C2)=O)C=C1)=O

Molecular Formula

C27H31N3O5

Molecular Weight

477.55

Precautions

P210-P233-P240-P241-P242-P243-P260-P261-P264-P270-P271-P280-P302+P352-P303+P361+P353-P304+P340-P308+P311-P330-P361+P364-P370+P378-P403+P233-P403+P235-P405-P501

References & Citations

[1]Salisbury CM, et al., Optimization of activity-based probes for proteomic profiling of histone deacetylase complexes. J Am Chem Soc. 2008 Feb 20;130 (7) :2184-94.