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CCT369260

CCT369260 (compound 1), a chemical probe, is an orally avtive B-cell lymphoma 6 (BCL6) inhibitor with anti-tumor activity. CCT369260 (compound 1) exhibits an IC50 of 520 nM[1].

Product Specifications

CAS Number

2647503-57-7

UNSPSC

12352005

Target

Bcl-2 Family; Molecular Glues

Type

Reference compound

Related Pathways

Apoptosis; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bcl6-in-3.html

Purity

99.67

Solubility

DMSO : 300 mg/mL (ultrasonic)

Smiles

O=C1N(CCC(C)(O)C)C2=CC(NC3=NC(N4C[C@@H](C)C(F)(F)[C@@H](C)C4)=NC=C3Cl)=CC=C2N1C

Molecular Formula

C24H31ClF2N6O2

Molecular Weight

508.99

References & Citations

[1]Benjamin R Bellenie, et al. Achieving In Vivo Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders. J Med Chem. 2020 Apr 23;63 (8) :4047-4068.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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