Flesinoxan (hydrochloride)
Flesinoxan hydrochloride is a hypotensive agent and a potent, high affinity and selective 5-hydroxytryptamine1A (5-HT1A) receptor agonist with an EC50 value of 24 nM. Flesinoxan hydrochloride also has effective anxiolytic/antidepressant effects[1][2][3].
Product Specifications
CAS Number
98205-89-1
Product Name Alternative
DU-29373
UNSPSC
12352101
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/flesinoxan-hydrochloride.html
Smiles
OC[C@H]1OC2=CC=CC(N3CCN(CC3)CCNC(C4=CC=C(C=C4)F)=O)=C2OC1.Cl
Molecular Formula
C22H27ClFN3O4
Molecular Weight
451.92
References & Citations
[1]Hadrava V, et al. Characterization of 5-hydroxytryptamine1A properties of flesinoxan: in vivo electrophysiology and hypothermia study. Neuropharmacology. 1995 Oct;34 (10) :1311-26.|[2]Schoeffter P, et al. Centrally acting hypotensive agents with affinity for 5-HT1A binding sites inhibit forskolin-stimulated adenylate cyclase activity in calf hippocampus. Br J Pharmacol. 1988 Nov;95 (3) :975-85.|[3]Rodgers RJ, et al. Antianxiety and behavioral suppressant actions of the novel 5-HT1A receptor agonist, flesinoxan. Pharmacol Biochem Behav. 1994 Aug;48 (4) :959-63.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor
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