MAP4K4-IN-6
MAP4K4-IN-6 (Compound 15f) is a MAP4K4 inhibitor (IC50: 80 nM) . MAP4K4-IN-6 reduces the c-Jun phosphorylation. MAP4K4-IN-6 has neuroprotective effects. MAP4K4-IN-6 increases the viability of motor neurons. MAP4K4-IN-6 can be used for research of Amyotrophic lateral sclerosis (ALS) [1].
Product Specifications
UNSPSC
12352211
Target
JNK; MAP4K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/map4k4-in-6.html
Smiles
O=C(NC)C(S1)=C(NC(N)=O)C=C1C2=CC=C(C(F)(F)F)C=C2
Molecular Formula
C14H12F3N3O2S
Molecular Weight
343.32
References & Citations
[1]Hattori H, et al. Discovery of 5-phenyl-3-ureidothiophene-2-carboxamides as protective agents for ALS patient iPSC-derived motor neur
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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