Phe-Lys (Trt) -PAB
Phe-Lys (Trt) -PAB is a cathepsin cleavable ADC linker used for the antibody-drug conjugates (ADCs) [1].
Product Specifications
CAS Number
[1116085-99-4]
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/phe-lys-trt-pab.html
Purity
96.24
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
OCC(C=C1)=CC=C1NC([C@@H](NC([C@@H](N)CC2=CC=CC=C2)=O)CCCCNC(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)=O
Molecular Formula
C41H44N4O3
Molecular Weight
640.81
Precautions
H302, H315, H319, H335
References & Citations
[1]Abu Ajaj K, et al. Development of protein-binding bifunctional linkers for a new generation of dual-actingprodrugs. Bioconjug Chem. 2009 Feb;20 (2) :390-6.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker; Protease Cleavable Linker
Available Sizes
Curated Selection
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