ATC-324
ATC-324 is an bivalent AR (Androgen Receptor) degrader based on the protein degradation technology platform AUTOphagy-TArgeting Chimera (AUTOTAC). ATC-324 induces the formation of AR/p62 complex, leading to autophagy-lysosomal degradation of AR. ATC-324 can reduce nuclear AR levels and downregulate target gene expression of AR and AR-v7, and also has a degradation effect on common AR mutants in PCa[1]. ATC-324 is composed of target-binding ligand (TBL) Enzalutamide and p62/SQSTM1 autophagy-targeting ligand (ATL) YT 6-2 analog-1 (HY-169386), connected by Boc-NH-PEG4-CH2CH2NH2 (HY-W008352). Among them, the active control of the target protein ligand is Enzalutamide carboxylic acid (HY-70002B), and the conjugate composed of the autophagy-targeting ligand and the linker is YT 6-2-PEG3-C2-NH2 (HY-169387).
Product Specifications
CAS Number
2925060-81-5
UNSPSC
12352005
Target
Androgen Receptor; AUTOTACs
Type
Reference compound
Related Pathways
PROTAC; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/atc-324.html
Smiles
O=C(NCCOCCOCCOCCOCCNC[C@@H](O)COC1=CC=C(OCC2=CC=C(F)C=C2)C(OCC3=CC=C(F)C=C3)=C1)C4=CC=C(N(C(N5C6=CC=C(C#N)C(C(F)(F)F)=C6)=S)C(C)(C)C5=O)C=C4F
Molecular Formula
C53H55F6N5O10S
Molecular Weight
1068.09
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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