E7130
E7130 is a microtubule inhibitor, which ameliorates the tumor microenvironment through suppression of cancer-associated fibroblasts (CAF) and promotion of tumor vasculature remodeling[1].
Product Specifications
UNSPSC
12352005
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/e7130.html
Solubility
10 mM in DMSO
Smiles
O=C(C[C@@H]1O[C@@]([C@H](O[C@]2(CC3)O[C@H]4[C@H]5C2)[C@H](O5)[C@@]4([H])O6)([H])[C@]6([H])CC1)O[C@H]([C@H]7C)[C@H](C[C@H]8O[C@@H](CC[C@H]9C(C[C@@H]3O9)=C)C[C@@H](C)C8=C)O[C@@]([C@@]7([H])O%10)([H])C[C@@]([C@@]%10([H])C%11)([H])O[C@@]%11(O%12)C[C@]([C@]%12([H])[C@@H](C)C%13)([H])O[C@@]%14%13C[C@H](C)[C@]%15([H])O[C@H](CN)[C@H](O)C[C@]%15([H])O%14
Molecular Formula
C58H83NO17
Molecular Weight
1066.28
References & Citations
[1]Kawano S, et al., A landmark in drug discovery based on complex natural product synthesis. Sci Rep. 2019 Jun 17;9 (1) :8656.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
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