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Siglec-15, Cynomolgus (HEK293, His-Avi)

Siglec-15 Protein, a Siglec family member and type-1 transmembrane protein, is constitutively expressed in osteoclasts, macrophages and dendritic cells. Siglec-15 plays a pivotal role in the development and differentiation of osteoclastogenesis, inhibiting antigen-specific T cell responses in vitro and in vivo. Siglec-15 Protein, Cynomolgus (HEK293, His-Avi) is the recombinant cynomolgus-derived Siglec-15 protein, expressed by HEK293 , with C-His, C-Avi labeled tag.

Product Specifications

Product Name Alternative

Siglec-15 Protein, Cynomolgus (HEK293, His-Avi), Cynomolgus, HEK293

UNSPSC

12352202

Type

Recombinant Proteins

Assay Protocol

https://www.medchemexpress.com/cytokines/siglec-15-protein-cynomolgus-hek293-his-avi.html

Molecular Formula

102126346 (Gene_ID) XP_005586866.2 (M60-T322) (Accession)

Molecular Weight

Approximately 33-43 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

References & Citations

[1]Angata T. Siglec-15: a potential regulator of osteoporosis, cancer, and infectious diseases. J Biomed Sci. 2020 Jan 3;27 (1) :10.|[2]Wang J, et al. Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy. Nat Med. 2019 Apr;25 (4) :656-666.|[3]Kang FB, et al. The diverse functions of Siglec-15 in bone remodeling and antitumor responses. Pharmacol Res. 2020 May;155:104728.|[4]Rashid S, et al. Molecular structure, expression, and the emerging role of Siglec-15 in skeletal biology and cancer. J Cell Physiol. 2022 Mar;237 (3) :1711-1719.

Shipping Conditions

Room temperature in continental US; may vary elsewhere.

Scientific Category

Recombinant Proteins

Frequently Asked Questions

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