ALDH1A1-IN-4
ALDH1A1-IN-4 (compound A1) is a potent inhibitor of aldehyde dehydrogenase (ALDH) A1, with IC50 value of 0.32 μM. ALDH1A1-IN-4 plays an important role in cancer research[1].
Product Specifications
CAS Number
[23982-86-7]
UNSPSC
12352005
Target
Aldehyde Dehydrogenase (ALDH)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/aldh1a1-in-4.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC=C(C2=NC3=CC=CC=C3N2CC4=CC=CC=C4)C=C1
Molecular Formula
C20H15ClN2
Molecular Weight
318.80
References & Citations
[1]Gera Narendra, et al. Scaffold hopping based designing of selective ALDH1A1 inhibitors to overcome cyclophosphamide resistance: synthesis and biological evaluation. RSC Med Chem. 2023 Nov 30;15 (1) :309-321.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ALDH1
Curated Selection
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