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Ornipressin

Ornipressin (POR-8) is a vasopressin agonist specific for the V1 receptor. Ornipressin can be used as a local vasoconstrictor. Ornipressin can reverse the hypotension associated with combine general/epidural anesthesia. Ornipressin has antidiuretic activity. Ornipressin decreases renal vascular resistance and increases renal blood flow in renal failure model[1][2][3][4].

Product Specifications

CAS Number

3397-23-7

Product Name Alternative

POR-8

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Vasopressin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Ornipressin.html

Purity

99.90

Solubility

DMSO : 22.22 mg/mL (ultrasonic; adjust pH to 3 with 1 M HCl)

Smiles

O=C([C@H](CSSC[C@@H](C(N[C@H](C1=O)CC2=CC=C(O)C=C2)=O)N)NC([C@@H](NC([C@@H](NC([C@](N1)([H])CC3=CC=CC=C3)=O)CCC(N)=O)=O)CC(N)=O)=O)N(CCC4)[C@@H]4C(N[C@@H](CCCN)C(NCC(N)=O)=O)=O

Molecular Formula

C45H63N13O12S2

Molecular Weight

1042.19

Precautions

H302, H315, H319, H335

References & Citations

[1]Fruhstorfer H, et al. Dose-response relation of ornipressin with regard to vasoconstriction in human skin. Br J Anaesth. 1994 Aug;73 (2) :220-4.|[2]De Kock M, et al. Ornipressin (Por 8) : An efficient alternative to counteract hypotension during combined general/epidural anesthesia. Anesth Analg. 2000 Jun;90 (6) :1301-7.|[3]Kam, P. C., & Tay, T. M. (1998) . The pharmacology of ornipressin (POR-8) : a local vasoconstrictor used in surgery. European journal of anaesthesiology, 15 (2), 133–139.|[4]Lenz, K., et al., (1991) . Ornipressin in the treatment of functional renal failure in decompensated liver cirrhosis. Effects on renal hemodynamics and atrial natriuretic factor. Gastroenterology, 101 (4), 1060–1067.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

Launched

Available Sizes

Frequently Asked Questions

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