CBP/p300-IN-20
CBP/p300-IN-20 is a potent and selective p300/CBP inhibitor, with a pIC50 of 10.1 for p300. CBP/p300-IN-20 can be used for the research of cancer[1].
Product Specifications
CAS Number
[2999742-92-4]
UNSPSC
12352005
Target
Epigenetic Reader Domain; Histone Acetyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cbp-p300-in-20.html
Purity
98.03
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C([C@@H]1N(C(C2(CC(F)(F)C2)C3=CC=C(Cl)C=C3)=O)C[C@H](F)C1)NC4=CC=C5NN=CC5=N4
Molecular Formula
C22H19ClF3N5O2
Molecular Weight
477.87
References & Citations
[1]Tian X, et, al. Discovery of Proline-Based p300/CBP Inhibitors Using DNA-Encoded Library Technology in Combination with High-Throughput Screening. J Med Chem. 2022 Nov 10;65 (21) :14391-14408.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CBP/p300
Available Sizes
Curated Selection
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