YD1342
YD1342 is a prodrug of YD1130, which exhibits potent inhibitory effects on cellular substrate methylation, breast cancer cell clonogenicity, and tumor growth in animal models, exceeding or matching known PRMT4-specific inhibitors.[1].
Product Specifications
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/yd1342.html
Smiles
NC1=NC=NC2=C1N=CN2[C@@H]3O[C@H](CSCCN(C(CC(C)(C)C(C(C(C)=C4C)=O)=C(C)C4=O)=O)CC5=CC(Br)=CC=C5)[C@@H](O)[C@H]3O
Molecular Formula
C33H39BrN6O6S
Molecular Weight
727.67
References & Citations
[1]Deng Y, et al. An Adenosine Analogue Library Reveals Insights into Active Sites of Protein Arginine Methyltransferases and Enables the Discovery of a Selective PRMT4 Inhibitor. J Med Chem. 2024 Oct 24;67 (20) :18053-18069.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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