Sarizotan (dihydrochloride)
Sarizotan dihydrochloride (EMD 128130) is an orally active serotonin 5-HT1A receptor and dopamine receptor agonist. Sarizotan (EMD 128130) exhibits IC50 values of 6.5 nM (rat 5-HT1A), 0.1 nM (human 5-HT1A), 15.1 nM (rat D2), 17 nM (human D2), 6.8 nM (human D3) and 2.4 nM (human D4.2), respectively[1].
Product Specifications
CAS Number
177976-12-4
Product Name Alternative
EMD 128130 (dihydrochloride)
UNSPSC
12352005
Target
5-HT Receptor; Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sarizotan-dihydrochloride.html
Smiles
FC(C=C1)=CC=C1C2=CN=CC(CNC[C@@H]3OC4=CC=CC=C4CC3)=C2.Cl.Cl
Molecular Formula
C22H23Cl2FN2O
Molecular Weight
421.34
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
5-HT1 Receptor; D3 Receptor; mLAG-3; MUC2; MUC3; Prostaglandin D Synthase; α-1 microglobulin
Available Sizes
Frequently Asked Questions
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