Human Proteinase 3 (PR-3) from Neutrophil Native

<strong>Human Proteinase 3 (PR-3) from Neutrophil Native</strong>_x000D_ <strong>Catalog number:</strong> B2017055_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 50 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 29 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -80°C_x000D_ <strong>Keywords:</strong> Myeloblastin, C-ANCA antigen, Leukocyte proteinase 3, PR-3, Neutrophil proteinase 4, NP-4, P29, Wegener autoantigen, AGP7_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Surmiak M, Kaczor M, Sanak M. Proinflammatory genes expression in granulocytes activated by native proteinase-binding fragments of anti-proteinase 3 IgG J Physiol Pharmacol. 2015 Aug;66(4):609-15._x000D_ 2: Kitamura M, Dasgupta A, Henricks J, Parikh SV, Nadasdy T, Clark E, Bazan JA, Satoskar AA. Clinicopathological differences between Bartonella and other bacterial endocarditis-related glomerulonephritis - our experience and a pooled analysis Front Nephrol. 2024 Jan 15;3:1322741._x000D_ 3: Rao NV, Wehner NG, Marshall BC, Gray WR, Gray BH, Hoidal JR. Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase. Structural and functional properties J Biol Chem. 1991 May 25;266(15):9540-8._x000D_ 4: Fu Z, Thorpe M, Akula S, Chahal G, Hellman LT. Extended Cleavage Specificity of Human Neutrophil Elastase, Human Proteinase 3, and Their Distant Ortholog Clawed Frog PR3-Three Elastases With Similar Primary but Different Extended Specificities and Stability Front Immunol. 2018 Oct 16;9:2387._x000D_ 5: Kao RC, Wehner NG, Skubitz KM, Gray BH, Hoidal JR. Proteinase 3. A distinct human polymorphonuclear leukocyte proteinase that produces emphysema in hamsters J Clin Invest. 1988 Dec;82(6):1963-73._x000D_ 6: Mayet WJ, Schwarting A, Meyer zum Büschenfelde KH. Cytotoxic effects of antibodies to proteinase 3 (C-ANCA) on human endothelial cells Clin Exp Immunol. 1994 Sep;97(3):458-65._x000D_ 7: Mayet WJ, Schwarting A, Orth T, Sibelius U, Hattar K, Meyer zum Büschenfelde KH. Signal transduction pathways of membrane expression of proteinase 3 (PR-3) in human endothelial cells Eur J Clin Invest. 1997 Nov;27(11):893-9._x000D_ 8: Rao NV, Wehner NG, Marshall BC, Sturrock AB, Huecksteadt TP, Rao GV, Gray BH, Hoidal JR. Proteinase-3 (PR-3): a polymorphonuclear leukocyte serine proteinase Ann N Y Acad Sci. 1991;624:60-8._x000D_ 9: Armstrong L, Godinho SI, Uppington KM, Whittington HA, Millar AB. Contribution of TNF-alpha converting enzyme and proteinase-3 to TNF-alpha processing in human alveolar macrophages Am J Respir Cell Mol Biol. 2006 Feb;34(2):219-25._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/8353286">10: Mayet WJ, Csernok E, Szymkowiak C, Gross WL, Meyer zum Büschenfelde KH. Human endothelial cells express proteinase 3, the target antigen of anticytoplasmic antibodies in Wegener's granulomatosis Blood. 1993 Aug 15;82(4):1221-9.</a>_x000D_ _x000D_ <strong>Products Related to Human Proteinase 3 (PR-3) from Neutrophil Native can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>