TTK ligand 3
TTK ligand 3 (Compound 5) is a ligand of monopolar spindle 1 (Mps1, TTK) that can be used in the synthesis of PROTAC.
Product Specifications
UNSPSC
12352211
Target
Ligands for Target Protein for PROTAC; Mps1
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ttk-ligand-3.html
Purity
99.50
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=S(C1=CC=CC=C1NC2=C3N=CNC3=NC(NC4=CC=C(N5CCNCC5)C=C4)=N2)(C(C)C)=O
Molecular Formula
C24H28N8O2S
Molecular Weight
492.60
References & Citations
[1]Sflakidou E, et, al. Development of 2-Aminoadenine-Based Proteolysis-Targeting Chimeras (PROTACs) as Novel Potent Degraders of Monopolar Spindle 1 and Aurora Kinases. ACS Pharmacol. Transl. Sci. 2024.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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