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TPC2-A1-P

TPC2-A1-P is a powerful and membrane permeable agonist of two pore channel 2 (TPC2) with an EC50 of 10.5 μM. TPC2-A1-P plays its role by mimicking the physiological actions of PI (3,5) P2. TPC2-A1-P also shows higher potency to induce Na2+ mobilisation from TPC2 than TPC-A1-N. TPC2-A1-P can be used to probe different functions of TPC2 channels in intact cells[1][2][3].

Product Specifications

CAS Number

2804595-86-4

UNSPSC

12352005

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/tpc2-a1-p.html

Purity

99.79

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

BrC1=CC(C2=CC(C(O)=O)=C(C)N2CC3CCCCC3)=C(OC(F)(F)F)C=C1

Molecular Formula

C20H21BrF3NO3

Molecular Weight

460.28

References & Citations

[1]Susanne Gerndt, et al. Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function. Elife. 2020 Mar 16;9:e54712.|[2]Xuhui Jin, et al. Targeting Two-Pore Channels: Current Progress and Future Challenges. Trends Pharmacol Sci. 2020 Aug;41 (8) :582-594.|[3]Gerndt S, et al. Discovery of lipophilic two-pore channel agonists. FEBS J. 2020;287 (24) :5284-5293.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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