PROTAC TBK1 degrader-2

PROTAC TBK1 degrader-2 is a Ligands for Target Protein for PROTAC. PROTAC TBK1 degrader-2 is a potent degrader based on the serine/threonine kinase TANK-binding kinase 1 (TBK1) (DC50=15 nM; Kd=4.6 nM) with a maximum efficiency of 96%. PROTAC TBK1 degrader-2 also targets to IkB kinase IKKε (IC50=8.7 nM), with low selectivity over TBK1 (IC50=1.3 nM) [1].

Product Specifications

CAS Number

[2052306-13-3]

UNSPSC

12352005

Target

IKK; PROTACs

Type

Reference compound

Related Pathways

NF-κB; PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-tbk1-degrader-2.html

Purity

98.20

Solubility

DMSO : 110 mg/mL (ultrasonic; warming)

Smiles

O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)NC(COCCCOCCCCOCCCOC4=CC=C(NC5=NC=C(Br)C(NCCCN(C(C6CCC6)=O)C)=N5)C=C4)=O)=O)C[C@H](O)C3

Molecular Formula

C53H74BrN9O9S

Molecular Weight

1093.18

References & Citations

[1]Crew AP, et al. Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1. J Med Chem. 2018 Jan 25;61 (2) :583-598.