Dauricumine

Dauricumine is a chlorinated alkaloid that inhibits NF-κB ligand-induced differentiation of mouse bone marrow-derived macrophages into multinucleated osteoclasts[1][2].

Product Specifications

CAS Number

[345641-00-1]

UNSPSC

12352005

Target

NF-κB

Type

Natural Products

Related Pathways

NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/dauricumine.html

Solubility

10 mM in DMSO

Smiles

COC([C@@]12[C@](C3)(CCN2C)[C@@]4([C@H](C1)Cl)[C@H](C(OC)=CC4=O)O)=C(OC)C3=O

Molecular Formula

C19H24ClNO6

Molecular Weight

397.85

References & Citations

[1]Sugimoto Y, et, al. Chlorinated alkaloids in Menispermum dauricum DC: root culture. J Org Chem. 2001 May 18;66 (10) :3299-302.|[2]Lee JY, et, al. Anti-osteoclastogenic effects of isoquinoline alkaloids from the rhizome extract of Sinomenium acutum. Arch Pharm Res. 2016 May;39 (5) :713-20.