Dechloro Rivaroxaban

Dechloro Rivaroxaban is a highly selective, orally active inhibitor of Factor Xa. Dechloro Rivaroxaban inhibits human free FXa with a Ki of 0.4 nM. Dechloro Rivaroxaban inhibits prothrombinase activity and fibrin-associated FXa activity with IC50s of 2.1 nM and 92 nM, respectively[1].

Product Specifications

CAS Number

[1415566-28-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Factor Xa

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/dechloro-rivaroxaban.html

Purity

99.68

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1N(C2=CC=C(N3C(COCC3)=O)C=C2)C[C@@H](O1)CNC(C4=CC=CS4)=O

Molecular Formula

C19H19N3O5S

Molecular Weight

401.44

Precautions

H302, H315, H319, H335

References & Citations

[1]Lang D, et al. In vitro metabolism of rivaroxaban, an oral, direct factor Xa inhibitor, in liver microsomes and hepatocytes of rats, dogs, and humans. Drug Metab Dispos. 2009 May;37 (5) :1046-55.