Citric acid
Product Specifications
UNSPSC Description
Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice[1][2][3].
Target Antigen
Antibiotic; Apoptosis; Endogenous Metabolite
Type
Natural Products
Related Pathways
Anti-infection;Apoptosis;Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection; Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Citric_acid.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)
Smiles
OC(CC(CC(O)=O)(C(O)=O)O)=O
Molecular Weight
192.12
References & Citations
[1]Chen X, et al. Study on injury effect of food additive citric acid on liver tissue in mice. Cytotechnology. 2014 Mar;66(2):275-82.|[2]Chen X, Lv Q, Liu Y, Deng W. Effects of the food additive, citric acid, on kidney cells of mice. Biotech Histochem. 2015 Jan;90(1):38-44. |[3]Ying TH, et al. Citric acid induces cell-cycle arrest and apoptosis of human immortalized keratinocyte cell line (HaCaT) via caspase- and mitochondrial-dependent signaling pathways. Anticancer Res. 2013 Oct;33(10):4411-20.Food Chem. 2022: 134807.|Nature. 2024 Dec 18.|New J Chem. 03 Aug 2022.|Adv Sci (Weinh). 2024 Oct 30:e2408707.|Carbohydr Polym. 2024 Dec 15:346:122645.|Exp Cell Res. 2020 Aug 1;393(1):112054.|Heliyon. 2024 Jan 17.|J Ethnopharmacol. 2024 Jan 12:117759.|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.|J Nanobiotechnology. 2023 Oct 19;21(1):383.|Nat Commun. 2024 Sep 10;15(1):7923.|Nature. 2023 Jun;618(7964):374-382.|Phytother Res. 2024 Mar 25.|SSRN. 2024 Mar 20.|Theranostics. 2020 Jul 25;10(21):9477-9494. |Bioengineered. 2021 Dec;12(2):11610-11621.|Biol Trace Elem Res. 2023 May 8.|Biomed Pharmacother. 2023 Aug 18;166:115333.|Drug Des Devel Ther. 2024 Feb 1:18:259-275.|Front Immunol. 2024 Oct 1:15:1397727.|Front Mol Biosci. 22 July 2022.|Int J Biol Sci. 2024 Aug 6;20(11):4222-4237.|Oxid Med Cell Longev. 2022 Apr 25;2022:3846217.|Research Square Preprint. 2021 Jul.|Insect Biochem Mol Biol. 2023 May 12;103958.|J Virol. 2023 Jun 22;e0051223.|Regen Biomater. 2024 Aug 22:11:rbae098.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N1428/Citric-acid-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N1428/Citric-acid-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
77-92-9
Available Sizes
Curated Selection
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