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VU6036720 (hydrochloride)

VU6036720 hydrochloride is a potent and specific in vitro inhibitor of Kir4.1/5.1. VU6036720 hydrochloride can inhibit Kir4.1/5.1 channels with an IC50 value of 0.24 μM. VU6036720 hydrochloride can be used for the research of brain and kidney[1].

Product Specifications

UNSPSC

12352005

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/vu6036720-hydrochloride.html

Concentration

10mM

Purity

99.65

Solubility

DMSO : 40 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C[C@H]1CN(CCN1CCNS(=O)(C2=CC(Cl)=C(C=C2)F)=O)C3=C(C#N)C=CC=C3.[H]Cl

Molecular Formula

C20H23Cl2FN4O2S

Molecular Weight

473.39

References & Citations

[1]Samantha J McClenahan, et al. VU6036720: The First Potent and Selective In Vitro Inhibitor of Heteromeric Kir4.1/5.1 Inward Rectifier Potassium Channels. Mol Pharmacol. 2022 May;101 (5) :357-370.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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