Clausine E
Clausine E, is a alkaloid which can be isolated from Clausena excavata, is a inhibitor of fat mass and obesity-associated protein (FTO) demethylase. Clausine E shows inhibitory activities against proliferation of synoviocytes and cancer cells.
Product Specifications
CAS Number
182261-83-2
Product Name Alternative
Clauszoline I
UNSPSC
12352005
Target
Others
Type
Natural Products
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/clausine-e.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC2=C(NC3=C2C=CC=C3)C(O)=C1)OC
Molecular Formula
C14H11NO3
Molecular Weight
241.24
References & Citations
[1]Wang Y, Li J, Han X, et al. Identification of Clausine E as an inhibitor of fat mass and obesity-associated protein (FTO) demethylase activity. J Mol Recognit. 2019;32 (10) :e2800. |[2]Guo JM, Yu XM, Jiang B, et al. Zhongguo Zhong Yao Za Zhi. 2021;46 (17) :4438-4445. |[3]Liger F, Popowycz F, Besson T, Picot L, Galmarini CM, Joseph B. Synthesis and antiproliferative activity of clausine E, mukonine, and koenoline bioisosteres. Bioorg Med Chem. 2007;15 (16) :5615-5619.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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