Apo-Bovine Transferrin

Apo-Bovine Transferrin refers to iron free Transferrin (HY-P3267), serves as Transferrin receptor ligand and mediates iron release from endothelial cells. Apo-Transferrin can directly bind to hephaestin, which can convert Fe2+ to Fe3+. Apo-Transferrin mediates iron efflux most likely in cooperation with ferroportin 1. Apo-Bovine Transferrin can be used in neuroretinal research[1][2].

Product Specifications

CAS Number

[11096-37-0]

UNSPSC

12352200

Hazard Statement

H315, H319, H335

Target

Ferroportin; Transferrin Receptor

Type

Biochemical Assay Reagents

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/apo-transferrin.html

Purity

95.0

Solubility

H2O : 25 mg/mL (ultrasonic)

Smiles

[Apo-BovineTransferrin]

Precautions

H315, H319, H335

References & Citations

[1]Baringer SL, et al. Apo- and holo- transferrin differentially interact with ferroportin and hephaestin to regulate iron release at the blood-brain barrier. bioRxiv [Preprint]. 2023 Jan 10:2023.01.10.522344.|[2]Bruinink A, et al. Neurotrophic effects of transferrin on embryonic chick brain and neural retinal cell cultures. Int J Dev Neurosci. 1996 Oct;14 (6) :785-95.