Exserohilone
Product Specifications
UNSPSC Description
Exserohilone ((-)-Exserohilone) is a thiodiketopiperazine derivative that exhibits the inhibition of TNF-α-induced ROS generation and MMP-1 secretion. Exserohilone increases the procollagen type I α1 secretion in human dermal fibroblasts[1].
Target Antigen
Reactive Oxygen Species
Type
Natural Products
Related Pathways
Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/exserohilone.html
Solubility
10 mM in DMSO
Smiles
CS[C@@]12N(C([C@@]3(N([C@]4([H])[C@@](C(C=C[C@H]4O)=O)([H])C3)C2=O)SC)=O)[C@]5([H])[C@@](C(C=C[C@H]5O)=O)([H])C1
Molecular Weight
450.53
References & Citations
[1]Haeun Kwon, et al. Mass spectrometry-guided isolation of thiodiketopiperazines from an EtOAc-extract of Setosphaeria rostrata culture medium and their anti-skin aging effects on TNF-α-induced human dermal fibroblasts. J Antibiot (Tokyo). 2024 Jan 19.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N12653/Exserohilone-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N12653/
Clinical Information
No Development Reported
CAS Number
99572-22-2
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