Exserohilone

Exserohilone ((-) -Exserohilone) is a thiodiketopiperazine derivative that exhibits the inhibition of TNF-α-induced ROS generation and MMP-1 secretion. Exserohilone increases the procollagen type I α1 secretion in human dermal fibroblasts[1].

Product Specifications

CAS Number

[99572-22-2]

Product Name Alternative

(-) -Exserohilone

UNSPSC

12352005

Target

Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/exserohilone.html

Solubility

10 mM in DMSO

Smiles

CS[C@@]12N(C([C@@]3(N([C@]4([H])[C@@](C(C=C[C@H]4O)=O)([H])C3)C2=O)SC)=O)[C@]5([H])[C@@](C(C=C[C@H]5O)=O)([H])C1

Molecular Formula

C20H22N2O6S2

Molecular Weight

450.53

References & Citations

[1]Haeun Kwon, et al. Mass spectrometry-guided isolation of thiodiketopiperazines from an EtOAc-extract of Setosphaeria rostrata culture medium and their anti-skin aging effects on TNF-α-induced human dermal fibroblasts. J Antibiot (Tokyo) . 2024 Jan 19.