Allopurinol (sodium)

Allopurinol sodium is a potent and orally active xanthine oxidase inhibitor with an IC50 value of 0.2-50 μM. Allopurinol sodium can be used in the research of hyperuricemia and gout. Allopurinol sodium decreases the expression of HIF-1α and HIF-2α protein. Allopurinol sodium shows anti-depressant and anti-nociception activity. Anti-leishmanial effect[1][2][3][4][5].

Product Specifications

CAS Number

[17795-21-0]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Xanthine Oxidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/allopurinol-sodium.html

Purity

99.90

Solubility

H2O : 40 mg/mL (ultrasonic; adjust pH to 12 with 1 M NaOH)

Smiles

O=C1C2=C(NN=C2)N=CN1.[Na]

Molecular Formula

C5H4N4NaO

Molecular Weight

159.10

Precautions

H315, H319, H335

References & Citations

[1]Pacher P, et al. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev. 2006;58 (1) :87-114. |[2]Pfaller MA, et al. Antileishmanial effect of allopurinol. Antimicrob Agents Chemother. 1974;5 (5) :469-472. |[3]Karve AV, et al. Evaluation of effect of allopurinol and febuxostat in behavioral model of depression in mice. Indian J Pharmacol. 2013 May-Jun;45 (3) :244-7.|[4]Schmidt AP, et al. Anti-nociceptive properties of the xanthine oxidase inhibitor allopurinol in mice: role of A1 adenosine receptors. Br J Pharmacol. 2009 Jan;156 (1) :163-72.|[5]Sun Y, et al. Dose-dependent effects of allopurinol on human foreskin fibroblast cells and human umbilical vein endothelial cells under hypoxia. PLoS One. 2015 Apr 1;10 (4) :e0123649.