PROTAC ERα Degrader-7
PROTAC ERα Degrader-7 (compound i-320) is a potent estrogen receptor alpha (ERα) PROTAC degrader with a DC50 value of 0.000006 µM. PROTAC ERα Degrader-7 comprises a cereblon-binding moiety LBM linked to a ligand ERBM that binds ERα and comprises a benzofused partially saturated 6-membered carbocyclic or heterocyclic ring[1].
Product Specifications
CAS Number
3025781-93-2
UNSPSC
12352005
Target
Estrogen Receptor/ERR; PROTACs
Type
Reference compound
Related Pathways
PROTAC; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-erα-degrader-7.html
Solubility
10 mM in DMSO
Smiles
FC1(C[C@H](C2=CC=C(C=C2)C)[C@H](C3=CC=C(N4CCC(CC4)CN5CCN(C6=CC=C(C(N([C@@H]7C(NC(CC7)=O)=O)C8)=O)C8=C6)CC5)C=C3)C9=CC=C(O)C=C91)F
Molecular Formula
C46H49F2N5O4
Molecular Weight
773.91
References & Citations
[1]Alexander M. Taylor, et al. Estrogen receptor alpha degraders and use thereof. WO2024006781A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERα
Frequently Asked Questions
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