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Phlorizin

Phlorizin (Floridzin) is a non-selective SGLT inhibitor with Kis of 300 and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also a Na+/K+-ATPase inhibitor.

Product Specifications

CAS Number

[60-81-1]

Product Name Alternative

Floridzin

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Na+/K+ ATPase; SGLT

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Phlorizin.html

Concentration

10mM

Purity

99.93

Solubility

DMSO : ≥ 50 mg/mL|H2O : 1 mg/mL (ultrasonic)

Smiles

O=C(C1=C(O)C=C(O)C=C1O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O)CCC3=CC=C(O)C=C3

Molecular Formula

C21H24O10

Molecular Weight

436.41

Precautions

H302, H315, H319, H335

References & Citations

[1]Pajor AM, et al. Inhibitor binding in the human renal low- and high-affinity Na+/glucose cotransporters. J Pharmacol Exp Ther. 2008 Mar;324 (3) :985-91.|[2]Nakagawa A, et al. Localization of the phlorizin site on Na, K-ATPase in red cell membranes. J Biochem. 1977 May;81 (5) :1511-5.|[3]Chang WT, et al. Evaluation of the anti-inflammatory effects of phloretin and phlorizin in lipopolysaccharide-stimulated mouse macrophages. Food Chem. 2012 Sep 15;134 (2) :972-9.|[4]Katsuda Y, et al. Contribution of hyperglycemia on diabetic complications in obese type 2 diabetic SDT fatty rats: effects of SGLT inhibitor phlorizin. Exp Anim. 2015;64 (2) :161-9.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-N0143/Phlorizin-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-N0143/Phlorizin-SDS-MedChemExpress.pdf

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

SGLT1; SGLT2

Available Sizes

Curated Selection

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