SJB3-019A
SJB3-019A is a potent and novel USP1 inhibitor, 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells with IC50 of 0.0781 μM.
Product Specifications
CAS Number
[2070015-29-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Deubiquitinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SJB3-019A.html
Concentration
10mM
Purity
99.88
Solubility
DMSO : 10 mg/mL (ultrasonic)
Smiles
O=C1C2=C(OC(C3=CC=CN=C3)=N2)C(C4=CC=CC=C41)=O
Molecular Formula
C16H8N2O3
Molecular Weight
276.25
Precautions
H302, H315, H319
References & Citations
[1]Helena Mistry, et al. Small molecule inhibitors of USP1 target ID1 degradation in leukemic cells. Mol Cancer Ther Published OnlineFirst October 15, 2013.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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