SJB3-019A

SJB3-019A is a potent and novel USP1 inhibitor, 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells with IC50 of 0.0781 μM.

Product Specifications

CAS Number

[2070015-29-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Deubiquitinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/SJB3-019A.html

Concentration

10mM

Purity

99.88

Solubility

DMSO : 10 mg/mL (ultrasonic)

Smiles

O=C1C2=C(OC(C3=CC=CN=C3)=N2)C(C4=CC=CC=C41)=O

Molecular Formula

C16H8N2O3

Molecular Weight

276.25

Precautions

H302, H315, H319

References & Citations

[1]Helena Mistry, et al. Small molecule inhibitors of USP1 target ID1 degradation in leukemic cells. Mol Cancer Ther Published OnlineFirst October 15, 2013.