Anti-inflammatory agent 84

Anti-inflammatory agent 84 (Compound 4D) is a derivative of Coumarin (HY-N0709) with antimicrobial and anti-inflammatory activities. Anti-inflammatory agent 84 inhibits E. coli, Candida albicans, Staphylococcus aureus and methicillin-resistant S. aureus (MRSA), with MIC of 312, 156, 19 and 316 μg/mL, respectively. Anti-inflammatory agent 84 inhibits biofilm formation of S. aureus, E. coli and MRSA, with IC50 of 185, 321 and 99 μM, respectively. Anti-inflammatory agent 84 inhibits nitric oxide production in Lipopolysaccharide (HY-D1056) -stimulated RAW264.7 macrophage cell[1].

Product Specifications

CAS Number

[9007-83-4]

UNSPSC

12352005

Target

Bacterial; Fungal

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/anti-inflammatory-agent-84.html

Solubility

10 mM in DMSO

Smiles

O=C(C(C1=CSC(NS(=O)(C2=CC3=C(OC(C=C3)=O)C=C2)=O)=N1)=C4)OC5=C4C=CC=C5

Molecular Formula

C21H12N2O6S2

Molecular Weight

452.46

References & Citations

[1]Ahmed GE, et al., Synthesis, biofilm formation inhibitory, and inflammation inhibitory activities of new coumarin derivatives. Sci Rep. 2024 Apr 20;14 (1) :9106.