BMH-9
BMH-9 (Compound Z54) is a modulator for nuclear receptor subfamily 2, group F, member 6 (NR2F6) (also known as nuclear orphan receptor Ear2) [1]. BMH-9 is an activator for p53 signaling pathway through interaction with DNA. BMH-9 inhibits proliferation of human cancer cells, exhibits antitumor efficacy in NOD-SCID mouse models[1].
Product Specifications
CAS Number
457937-39-2
UNSPSC
12352005
Target
MDM-2/p53; Orphan Nuclear Receptor; Orphan Receptor
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bmh-9.html
Smiles
O=C(OCC)C1=C(C2=CC(C)=CC(C)=C2N=C1)NCCCN(C)C
Molecular Formula
C19H27N3O2
Molecular Weight
329.44
References & Citations
[1]Lander HM, et al., Small Molecule Agonists and Antagonists of NR2F6 Activity in Humans. US20180214413.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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