AP22408

AP22408 is a nonpeptide inhibitor against Src SH2 with an IC50 value of 0.3 μM. AP22408 inhibits rabbit osteoclast-mediated resorption of dentine, exhibits bone-targeting properties based on a hydroxyapatite adsorption assay and demonstrates in vivo antiresorptive activity in a parathyroid hormone-induced rat model. AP22408 is proming for rasearch of osteoporosis and other bone-related diseases such as Paget’s disease, osteolytic bone metastasis and hypercalcemia associated with malignancy[1].

Product Specifications

CAS Number

[268741-43-1]

UNSPSC

12352005

Target

Src

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ap22408.html

Smiles

O=C(N[C@H]1CCCCC2=CC(OCC3CCCCC3)=C(C(N)=O)C=C21)[C@@H](NC(C)=O)CC4=CC=C(P(O)(O)=O)C(P(O)(O)=O)=C4

Molecular Formula

C30H41N3O10P2

Molecular Weight

665.61

References & Citations

[1]Shakespeare W, et al. Structure-based design of an osteoclast-selective, nonpeptide src homology 2 inhibitor with in vivo antiresorptive activity. Proc Natl Acad Sci U S A. 2000 Aug 15;97 (17) :9373-8.