Oenothein B

Oenothein B is a dimeric macrocyclic ellagitannin and has widely pharmacological activities, including antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor properties. Oenothein B is a potent and specific inhibitor of poly (ADP-ribose) glycohydrolase[1][2].

Product Specifications

CAS Number

[104987-36-2]

UNSPSC

12352005

Target

Apoptosis; Bacterial; Fungal; HCV

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/oenothein-b.html

Purity

96.38

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1C2=CC(OC3=C(C4=O)C=C(O)C(O)=C3O)=C(O)C(O)=C2C5=C(C(OC[C@@H](O[C@@H](O)[C@H](OC(C6=C(OC7=C(O)C(O)=C(C8=C9C=C(O)C(O)=C8O)C(C(OC[C@H]%10O[C@@H](O)[C@H](O4)[C@@H](OC(C%11=CC(O)=C(O)C(O)=C%11)=O)[C@@H]%10OC9=O)=O)=C7)C(O)=C(O)C(O)=C6)=O)[C@H]%12OC(C%13=CC(O)=C(O)C(O)=C%13)=O)[C@H]%12O1)=O)C=C(O)C(O)=C5O

Molecular Formula

C68H48O44

Molecular Weight

1569.08

References & Citations

[1]Xiaodong Pei, et al. Oenothein B inhibits human non-small cell lung cancer A549 cell proliferation by ROS-mediated PI3K/Akt/NF-κB signaling pathway. Chem Biol Interact. 2019 Jan 25;298:112-120.|[2]Satoru Tamura, et al. Oenothein B, dimeric hydrolysable tannin inhibiting HCV invasion from Oenothera erythrosepala. J Nat Med. 2019 Jan;73 (1) :67-75.|[3]Satoshi Okuyama, et al. Oenothein B suppresses lipopolysaccharide (LPS) -induced inflammation in the mouse brain. Int J Mol Sci. 2013 May 7;14 (5) :9767-78.