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L-Palmitoylcarnitine-d9

L-Palmitoylcarnitine-d9 is deuterium labeled L-Palmitoylcarnitine. L-Palmitoylcarnitine, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2[1][1][2].

Product Specifications

CAS Number

2847775-90-8

UNSPSC

12352211

Target

Endogenous Metabolite; Isotope-Labeled Compounds; Potassium Channel

Type

Isotope-Labeled Compounds

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Others

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Cardiovascular Disease

Purity

99.0

Solubility

Ethanol : 25 mg/mL (ultrasonic; warming)

Smiles

CCCCCCCCCCCCCCCC(O[C@H](CC([O-])=O)C[N+](C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=O

Molecular Formula

C23H36D9NO4

Molecular Weight

408.66

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Haruna T, et al. Alteration of the membrane lipid environment by L-palmitoylcarnitine modulates K (ATP) channels in guinea-pig ventricular myocytes. Pflugers Arch. 2000;441 (2-3) :200-207.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Frequently Asked Questions

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