ADRA2A antagonist 1
ADRA2A antagonist 1 (compd 4n) is a potent and selective ADRA2A antagonist with an IC50 of 18 nM. ADRA2A antagonist 1 can be used for inflammation and sepsis research[1].
Product Specifications
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/adra2a-antagonist-1.html
Concentration
10mM
Purity
98.02
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
[H][C@]12C3=C(CCN1C[C@]4([H])CC[C@H](O)[C@H](C(O[C@H]5C[C@@H](C5)N)=O)[C@@]4([H])C2)C(C=CC=C6)=C6N3
Molecular Formula
C24H31N3O3
Molecular Weight
409.52
References & Citations
[1]Chayka A, et al. Structure-Based Drug Design of ADRA2A Antagonists Derived from Yohimbine. J Med Chem. 2024 Jun 10.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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