Adefovir-d4

Adefovir-d4 is the deuterium labeled Adefovir. Adefovir (GS-0393) is an adenosine monophosphate analog antiviral agent that after intracellular conversion to Adefovir diphosphate inhibits HBV DNA polymerase. Adefovir has an IC50 of 0.7 μM against HBV in the HepG2.2.15 cell line. Adefovir has good antiviral activity against several viruses, including HBV and herpesviruses[1][2][3].

Product Specifications

CAS Number

[1190021-70-5]

Product Name Alternative

GS-0393-d4; PMEA-d4

UNSPSC

12352005

Hazard Statement

H301, H312, H330, H410

Target

HBV; Isotope-Labeled Compounds; Reverse Transcriptase

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Others

Field of Research

Infection

Purity

98.69

Solubility

10 mM in DMSO

Smiles

O=P(O)(O)COC([2H])([2H])C([2H])([2H])N1C2=NC=NC(N)=C2N=C1

Molecular Formula

C8H8D4N5O4P

Molecular Weight

277.21

Precautions

H301, H312, H330, H410

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]X.-X.Zhou, et al. 7.11 - Deoxyribonucleic Acid Viruses: Antivirals for Herpesviruses and Hepatitis B Virus. Comprehensive Medicinal Chemistry II. Volume 7, 2007, Pages 295-327.|[3]Marcellin P, et al. Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B. N Engl J Med. 2003 Feb 27;348 (9) :808-16.|[4]Leah A.Burke, et al. 155 - Drugs to Treat Viral Hepatitis. Infectious Diseases. Volume 2, 2017, Pages 1327-1332.