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Esculetin (Standard)

Esculetin (Standard) is the analytical standard of Esculetin. This product is intended for research and analytical applications. Esculetin is an active ingredient extracted mainly from the bark of Fraxinus rhynchophylla. Esculetin inhibits platelet-derived growth factor (PDGF) -induced airway smooth muscle cells (ASMCs) phenotype switching through inhibition of PI3K/Akt pathway. Esculetin has antioxidant, antiinflammatory, and antitumor activities[1].

Product Specifications

CAS Number

305-01-1

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Akt; PI3K; Reference Standards

Type

Reference Standards

Related Pathways

Others; PI3K/Akt/mTOR

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/esculetin-standard.html

Purity

99.91

Smiles

O=C1C=CC2=CC(O)=C(O)C=C2O1

Molecular Formula

C9H6O4

Molecular Weight

178.14

Precautions

H302, H315, H319, H335

References & Citations

[1]Xie C, et al. Esculetin regulates the phenotype switching of airway smooth muscle cells. Phytother Res. 2019 Aug 21.|[2]Arora R, et al. Esculetin induces antiproliferative and apoptotic response in pancreatic cancer cells by directly binding to KEAP1. Mol Cancer. 2016 Oct 18;15 (1) :64. |[3]Chen Y, et al. Esculetin Ameliorates Psoriasis-Like Skin Disease in Mice by Inducing CD4+Foxp3+ Regulatory T Cells. Front Immunol. 2018 Sep 12;9:2092. |[4]Kim WK, et al. Esculetin suppresses tumor growth and metastasis by targeting Axin2/E-cadherin axis in colorectal cancer. Biochem Pharmacol. 2018 Jun;152:71-83.|[5]Martín-Aragón S, et al. Age-dependent effects of esculetin on mood-related behavior and cognition from stressed mice are associated with restoring brain antioxidant status. Prog Neuropsychopharmacol Biol Psychiatry. 2016 Feb 4;65:1-16.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, sealed storage, away from light and moisture

Scientific Category

Reference Standards

Available Sizes

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