1,2,3,6,7,8-Hexachlorodibenzofuran

1,2,3,6,7,8-Hexachlorodibenzofuran (1,2,3,6,7,8-HxCDF) is a dioxin-like polychlorinated dibenzofuran (PCDF) . 1,2,3,6,7,8-Hexachlorodibenzofuran induces expression of the genes encoding aryl hydrocarbon hydroxylase (AHH) and ethoxyresorufin-O-deethylase (EROD) in H-4-II-E rat hepatoma cells (EC50s = 1.47 and 1.24 nM, respectively) . 1,2,3,6,7,8-Hexachlorodibenzofuran reduces weight, induces thymic atrophy, and induces the expression of genes encoding the cytochrome P450 (CYP) isoform CYP1A1 and 4-chlorobiphenyl hydroxylase in rats (EC50s = 3.2, 0.9, 0.35, and 0.21 µmol/kg, respectively) [1][2][3].

Product Specifications

CAS Number

[57117-44-9]

Product Name Alternative

1,2,3,6,7,8-HxCDF

UNSPSC

12352005

Hazard Statement

H300-H310-H330-H410

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/1-2-3-6-7-8-hexachlorodibenzofuran.html

Smiles

ClC1=C(Cl)C(Cl)=C(OC2=CC(Cl)=C(Cl)C(Cl)=C23)C3=C1

Molecular Formula

C12H2Cl6O

Molecular Weight

374.86

Precautions

P260-P262-P264-P270-P271-P273-P280-P284-P302+P352-P304+P340-P330-P361+P364-P391-P403+P233-P405-P501

References & Citations

[1]Harnly M, et al. Polychlorinated Dibenzo-p-dioxin and Dibenzofuran Contamination at Metal Recovery Facilities, Open Burn Sites, and a Railroad Car Incineration Facility. Environ Sci Technol. 1995 Mar 1;29 (3) :677-84.|[2]Mason G, et al. Polychlorinated dibenzofurans (PCDFs) : correlation between in vivo and in vitro structure-activity relationships. Toxicology. 1985 Oct;37 (1-2) :1-12.|[3]Bandiera S, et al. Polychlorinated dibenzofurans (PCDFs) : effects of structure on binding to the 2,3,7,8-TCDD cytosolic receptor protein, AHH induction and toxicity. Toxicology. 1984 Aug;32 (2) :131-44.