VU0422288
VU0422288 (ML396) is a positive allosteric modulator of group III mGluRs. VU0422288 inhibits mGluRs with EC50s of 125 nM, 146 nM, and 108 nM for mGluR4, mGluR7, and mGluR8, respectively in calcium mobilization assays. VU0422288 reverses deficits in contextual fear memory, social recognition, and apneas in Rett syndrome (RTT) model mice[1][2].
Product Specifications
CAS Number
1630936-95-6
Product Name Alternative
ML396
UNSPSC
12352005
Hazard Statement
H302, H319
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vu0422288.html
Purity
99.94
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
ClC(C=C(NC(C1=CC=CC=N1)=O)C=C2)=C2OC3=CC=C(Cl)C=N3
Molecular Formula
C17H11Cl2N3O2
Molecular Weight
360.19
Precautions
H302, H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR4; mGluR7; mGluR8
Available Sizes
Frequently Asked Questions
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