VU0422288

VU0422288 (ML396) is a positive allosteric modulator of group III mGluRs. VU0422288 inhibits mGluRs with EC50s of 125 nM, 146 nM, and 108 nM for mGluR4, mGluR7, and mGluR8, respectively in calcium mobilization assays. VU0422288 reverses deficits in contextual fear memory, social recognition, and apneas in Rett syndrome (RTT) model mice[1][2].

Product Specifications

CAS Number

[1630936-95-6]

Product Name Alternative

ML396

UNSPSC

12352005

Hazard Statement

H302, H319

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/vu0422288.html

Purity

99.94

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

ClC(C=C(NC(C1=CC=CC=N1)=O)C=C2)=C2OC3=CC=C(Cl)C=N3

Molecular Formula

C17H11Cl2N3O2

Molecular Weight

360.19

Precautions

H302, H319

References & Citations

[1]Jalan-Sakrikar N, et al. Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7. ACS Chem Neurosci. 2014 Dec 17;5 (12) :1221-37. |[2]Gogliotti RG, et al. mGlu7 potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome. Sci Transl Med. 2017 Aug 16;9 (403) :eaai7459.