Anticancer agent 168
Product Specifications
UNSPSC Description
Anticancer agent 168 (compound d16) is a inhibitor of DNA2. Anticancer agent 168 induces apoptosis and cell-cycle arrest mainly at S-phase, and exhibits anticancer activities and overcomes chemotherapy resistance in mutp53-bearing cancers[1].
Target Antigen
Apoptosis; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/anticancer-agent-168-1.html
Solubility
DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
OC(C1=CN(CC)C2=CC(Cl)=C(C3=CC=C([N+]([O-])=O)O3)C=C2C1=O)=O
Molecular Weight
362.72
References & Citations
[1]Folly-Kossi H, et al. DNA2 Nuclease Inhibition Confers Synthetic Lethality in Cancers with Mutant p53 and Synergizes with PARP Inhibitors. Cancer Res Commun. 2023;3(10):2096-2112.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-155339/Anticancer-agent-168-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-155339/Anticancer-agent-168-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
9007-83-4
Available Sizes
Curated Selection
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