Anticancer agent 168
Anticancer agent 168 (compound d16) is a inhibitor of DNA2. Anticancer agent 168 induces apoptosis and cell-cycle arrest mainly at S-phase, and exhibits anticancer activities and overcomes chemotherapy resistance in mutp53-bearing cancers[1].
Product Specifications
CAS Number
207399-56-2
UNSPSC
12352005
Target
Apoptosis; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/anticancer-agent-168-1.html
Purity
99.55
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OC(C1=CN(CC)C2=CC(Cl)=C(C3=CC=C([N+]([O-])=O)O3)C=C2C1=O)=O
Molecular Formula
C16H11ClN2O6
Molecular Weight
362.72
References & Citations
[1]Folly-Kossi H, et al. DNA2 Nuclease Inhibition Confers Synthetic Lethality in Cancers with Mutant p53 and Synergizes with PARP Inhibitors. Cancer Res Commun. 2023;3 (10) :2096-2112.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
A07699-4-Fluoro647 100 µg/Vial
Anti-Sarcalumenin/Srl Antibody Picoband® Fluoro647 Conjugated
Sign In for Pricing
View Details 35268061 1.0 µg DNA
OR4X2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
Sign In for Pricing
View Details ![CD10 (MME) Mouse Monoclonal Antibody [Clone:3D11]](https://cdn.genprice.uk/genprice/uk/genprice5.webp)