Pralidoxime (methanesulfonate)
Pralidoxime methanesulfonate is a potent reactivator of acetylcholinesterase (AChE) . Pralidoxime methanesulfonate reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime methanesulfonate is an antidote for organophosphate poisoning[1][2].
Product Specifications
CAS Number
154-97-2
UNSPSC
12352005
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pralidoxime-methanesulfonate.html
Smiles
O=S([O-])(C)=O.O/N=C/C1=[N+](C)C=CC=C1
Molecular Formula
C8H12N2O4S
Molecular Weight
232.26
References & Citations
[1]Cadieux CL, et al. Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents. Chem Biol Interact. 2016;259 (Pt B) :133‐141.|[2]Eyer P, Buckley N. Pralidoxime for organophosphate poisoning. Lancet. 2006;368 (9553) :2110‐2111.|[3]Houzé P, et al. High Dose of Pralidoxime Reverses Paraoxon-Induced Respiratory Toxicity in Mice. Turk J Anaesthesiol Reanim. 2018;46 (2) :131‐138.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
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