Triclabendazole sulfoxide
Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole, and exhibits anti-parasite effects. Triclabendazole sulfoxide can inhibit membrane transporter ABCG2/BCRP[1][2].
Product Specifications
CAS Number
100648-13-3
Product Name Alternative
TCBZ-SO
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
BCRP; Parasite; PDGFR
Type
Reference compound
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/triclabendazole-sulfoxide.html
Purity
98.78
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(C1=NC2=CC(OC3=CC=CC(Cl)=C3Cl)=C(Cl)C=C2N1)C
Molecular Formula
C14H9Cl3N2O2S
Molecular Weight
375.66
Precautions
H302, H315, H319, H335
References & Citations
[1]Barrera B, et, al. The anthelmintic triclabendazole and its metabolites inhibit the membrane transporter ABCG2/BCRP. Antimicrob Agents Chemother. 2012 Jul;56 (7) :3535-43.|[2]Robinson MW, et, al. The comparative metabolism of triclabendazole sulphoxide by triclabendazole-susceptible and triclabendazole-resistant Fasciola hepatica. Parasitol Res. 2004 Feb;92 (3) :205-10.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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