CDK12-IN-E9
CDK12-IN-E9 is a potent and selective covalent CDK12 inhibitor and a non-covalent CDK9 inhibitor, while avoiding ABC transporter-mediated efflux. CDK12-IN-E9 has weak binding ability to CDK7/CyclinH complex with an IC50> 1 μM[1].
Product Specifications
CAS Number
2020052-55-3
Product Name Alternative
(1α,1'S,4β)-AZD3293; (1α,1'S,4β)-LY3314814
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk12-in-e9.html
Purity
99.71
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
C=CC(NC1=CC=CC(NC2=CC(N3[C@H](CCO)CCCC3)=NC4=C(CC)C=NN24)=C1)=O
Molecular Formula
C24H30N6O2
Molecular Weight
434.53
References & Citations
[1]Gao Y, et al. Overcoming Resistance to the THZ Series of Covalent Transcriptional CDK Inhibitors. Cell Chem Biol. 2018 Feb 15;25 (2) :135-142.e5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK12; CDK2; CDK7; CDK9
Available Sizes
Frequently Asked Questions
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PDP1 (Pyruvate Dehyrogenase Phosphatase Catalytic Subunit 1, PDH, PDP, PDP 1, PDPC, PDPC 1, PPM2C, Protein phosphatase 2C)